Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner.
Yong WangGuo LiBingni ChenGeorge ShakirMario VolzEmiel P.C. van der VorstSanne L MaasMartina GeigerCarolin JethwaAlexander BarteltZhaolong LiJustus WettichNadja SachsLars MaegdefesselMaliheh Nazari JahantighMichael HristovMichael LacyBeat LutzChristian WeberStephan HerzigRaquel Guillamat PratsSabine SteffensPublished in: Cardiovascular research (2024)
Impaired macrophage CB1 signaling is atheroprotective by limiting their arterial recruitment, proliferation and inflammatory reprogramming in male mice. The importance of macrophage CB1 signaling appears to be sex-dependent.