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Stemness, Pluripotentiality, and Wnt Antagonism: sFRP4, a Wnt antagonist Mediates Pluripotency and Stemness in Glioblastoma.

Gurubharathi BhuvanalakshmiNaisarg GamitManasi PatilFrank ArfusoGautam SethiArun DharmarajanAlan Prem KumarSudha Warrier
Published in: Cancers (2018)
This study unveils a novel nuclear role for sFRP4 to promote apoptosis by a possible activation of DNA damage machinery in glioblastoma.
Keyphrases
  • stem cells
  • dna damage
  • oxidative stress
  • epithelial mesenchymal transition
  • cell proliferation
  • endoplasmic reticulum stress
  • cell death
  • dna repair
  • cell cycle arrest
  • cancer stem cells