Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice.

Jessica L HoffmanSara P FaccidomoSeth M TaylorKristina G DeMiceliAshley M MayEvan N SmithCiarra M WhindletonClyde W Hodge

Published in: Psychopharmacology (2023)

This study reveals a novel brain region-specific role of TARP γ-8 bound AMPARs as a molecular mechanism of the positive reinforcing effects of alcohol and non-drug rewards.

Keyphrases

resting state
white matter
functional connectivity
transcription factor
alcohol consumption
cerebral ischemia
emergency department
protein protein
multiple sclerosis
small molecule
adverse drug