Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia.
Bas P H AdriaansenJohannes S KamphuisMariska A M SchröderAndré J OlthaarCarina BockAndré BrandtNike M M L StikkelbroeckEef G W M LentjesPaul N SpanFred C G J SweepHedi L Claahsen-van der GrintenAntonius E van HerwaardenPublished in: Clinical endocrinology (2022)
Good stability of the steroids in saliva enables saliva collection by the patient at home. Since salivary A4 and 17-OHP display a diurnal rhythm and age-dependent pattern, we established reference values for both children and adults at three time points during the day. These reference values support treatment monitoring of children and adults with CAH.