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Periplocoside P affects synaptic transmission at the neuromuscular junction and reduces synaptic excitability in Drosophila melanogaster by inhibiting V-ATPase.

Jiaojiao LuoAnqi SunYang YuYakun PeiYayun ZuoZhao-Nong Hu
Published in: Pest management science (2023)
Our findings confirm that PSP can influence synaptic transmission at the neuromuscular junction of Drosophila larvae by targeting V-ATPase. These results provide a basis for investigating the mechanism of action of PSP and its potential application in designing novel insecticides. This article is protected by copyright. All rights reserved.
Keyphrases
  • drosophila melanogaster
  • prefrontal cortex
  • aedes aegypti
  • signaling pathway
  • endoplasmic reticulum