Recurrence Risk in Patients with Cryptogenic Stroke, Patent Foramen Ovale, and Thrombophilia: A Systematic Review and Meta-Analysis.
Claus Vinter Bodker HviidClaus Ziegler SimonsenAnne-Mette HvasPublished in: Thrombosis and haemostasis (2019)
Thrombophilia is associated with an increased risk of recurrence in patients with PFO and cryptogenic stroke, which may persist after PFO closure. This suggests a need for antithrombotic therapy after PFO closure. Study heterogeneity precludes strong conclusions on antithrombotic treatment, but life-long antiplatelet therapy to patients without preexisting indication for anticoagulant therapy seems reasonable.
Keyphrases
- atrial fibrillation
- antiplatelet therapy
- percutaneous coronary intervention
- end stage renal disease
- acute coronary syndrome
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- free survival
- prognostic factors
- venous thromboembolism
- coronary artery disease
- cerebral ischemia
- brain injury
- patient reported