Activation of Notch1 signaling in podocytes by glucose-derived AGEs contributes to proteinuria.
Rajkishor NishadPrajakta MeshramAshish Kumar SinghG Bhanuprakash ReddyAnil Kumar PasupulatiPublished in: BMJ open diabetes research & care (2021)
The data suggest that AGEs activate Notch signaling in the glomerular podocytes. Pharmacological inhibition of Notch signaling by DAPT ameliorates AGE-induced podocytopathy and fibrosis. Our observations suggest that AGE-induced Notch reactivation in mature podocytes could be a novel mechanism in glomerular disease and thus could represent a novel therapeutic target.