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Sequential Single-Cell Transcriptional and Protein Marker Profiling Reveals TIGIT as a Marker of CD19 CAR-T Cell Dysfunction in Patients with Non-Hodgkin Lymphoma.

Zachary JacksonChangjin HongRobert SchaunerBoro DropulićPaolo F CaimiMarcos J deLimaMaria Florencia GiraudoKalpana GuptaJane S ReeseTae Hyun HwangDavid N Wald
Published in: Cancer discovery (2022)
This is the first study investigating the mechanisms linked to CAR-T patient responses based on the sequential analysis of manufactured and infused CAR-T cells using single-cell RNA and protein expression data. Furthermore, our findings are the first to demonstrate an improvement of CAR-T cell efficacy with TIGIT inhibition alone. This article is highlighted in the In This Issue feature, p. 1825.
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • gene expression
  • machine learning
  • oxidative stress
  • case report
  • transcription factor
  • big data
  • small molecule
  • binding protein
  • nucleic acid
  • heat shock
  • neural network