Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy.

Qiming Zhou Linhan Lei Junhong Cheng Junyou Chen Yuyang Du Xuehua Zhang Qing Li Chuangen LiHaijun DengChi Chun WongBaoxiong ZhuangGuoxin Li Xiaowu Bai

Published in: Gut (2024)

Our findings unravelled that dysfunctional goblet cells and consequential bacterial translocation activated the S100A11-RAGE axis in right-sided colon ADs, which recruits MDSCs to promote immune evasion. Targeting this axis by Azeliragon improves the efficacy of immunotherapy in colon cancer.

Keyphrases

induced apoptosis
cell cycle arrest
high glucose
endoplasmic reticulum stress