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Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water.

Xiaohan LiKarthik S IyerRuchita R ThakoreDavid K LeahyJ Daniel BaileyBruce H Lipshutz
Published in: Organic letters (2021)
Highly valued products resulting from reductive aminations utilizing shelf-stable bisulfite addition compounds of aldehydes can be made under aqueous micellar catalysis conditions. Readily available α-picolineborane serves as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished, and several applications to targets in the pharmaceutical industry are documented.
Keyphrases
  • ionic liquid