T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis.

Carolina CrucianiMarco PuthenparampilPaula Tomas-OjerIvan JelcicMaria Jose DocampoRaquel PlanasPraveena ManogaranRoland OpferCarla WickiMarkus ReindlIlijas JelcicAndreas LutterottiRoland MartinMireia Sospedra

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Our observations reveal an association between autoantigen reactivity and features of disease heterogeneity that strongly supports an important role of T-cell specificity in MS pathogenesis. These data have the potential to improve patient classification in clinical practice and to guide the development of antigen-specific tolerization strategies.

Keyphrases

multiple sclerosis
single cell
clinical practice
machine learning
case report
ms ms
electronic health record
white matter
big data
risk assessment
genome wide
structural basis