Macrophage Dysfunction in Autoimmune Rheumatic Diseases and Atherosclerosis.
Elena V GerasimovaTatiana V PopkovaDaria A GerasimovaTatiana V KirichenkoPublished in: International journal of molecular sciences (2022)
One of the problems of modern medical science is cardiovascular pathology caused by atherosclerotic vascular lesions in patients with autoimmune rheumatic diseases (ARDs). The similarity between the mechanisms of the immunopathogenesis of ARD and chronic low-grade inflammation in atherosclerosis draws attention. According to modern concepts, chronic inflammation associated with uncontrolled activation of both innate and acquired immunity plays a fundamental role in all stages of ARDs and atherosclerotic processes. Macrophage monocytes play an important role among the numerous immune cells and mediators involved in the immunopathogenesis of both ARDs and atherosclerosis. An imbalance between M1-like and M2-like macrophages is considered one of the causes of ARDs. The study of a key pathogenetic factor in the development of autoimmune and atherosclerotic inflammation-activated monocyte/macrophages will deepen the knowledge of chronic inflammation pathogenesis.
Keyphrases
- oxidative stress
- acute respiratory distress syndrome
- low grade
- extracorporeal membrane oxygenation
- mechanical ventilation
- cardiovascular disease
- multiple sclerosis
- healthcare
- drug induced
- immune response
- high grade
- dendritic cells
- adipose tissue
- mental health
- public health
- type diabetes
- working memory
- peripheral blood