Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs.
Henning CarstensKatharina KalkaRabea VerhaeghFabian SchumacherMatthias SoddemannBarbara WilkerSimone KeitschCarolin SehlBurkhard KleuserMichael HüblerUrsula RauenAnne Katrin BeckerAchim KochErich GulbinsMarkus KamlerPublished in: PloS one (2022)
Inhalation of sphingosine induced a significant decrease of Pseudomonas aeruginosa at the epithelial layer of tracheal and bronchial cells. The inhalation has no local side effects in ex-vivo perfused and ventilated pig lungs.
Keyphrases
- pseudomonas aeruginosa
- cystic fibrosis
- intensive care unit
- acute respiratory distress syndrome
- induced apoptosis
- biofilm formation
- acinetobacter baumannii
- staphylococcus aureus
- cell cycle arrest
- high glucose
- diabetic rats
- oxidative stress
- extracorporeal membrane oxygenation
- endoplasmic reticulum stress
- drug induced
- signaling pathway
- cell proliferation