Genome-wide association study identifies genetic susceptibility loci and pathways of radiation-induced acute oral mucositis.

Da-Wei YangTong-Min WangJiang-Bo ZhangXi-Zhao LiYong-Qiao HeRuowen XiaoWen-Qiong XueXiao-Hui ZhengPei-Fen ZhangShao-Dan ZhangYe-Zhu HuGuo-Ping ShenMingyuan ChenYing SunWei-Hua Jia

Published in: Journal of translational medicine (2020)

These results enhance the biological understanding of radiotherapy toxicity. The association signals enriched in telomere function regulation implicate the potential underlying mechanism and warrant further functional investigation and potential individual radiotherapy applications.

Keyphrases

radiation induced
genome wide association study
radiation therapy
genome wide
liver failure
early stage
human health
oxidative stress
locally advanced
respiratory failure
drug induced
copy number
gene expression
risk assessment
intensive care unit
rectal cancer
mechanical ventilation