Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease.

Athanasios MetaxasMarco AnzaloneRamanan VaitheeswaranSussanne PetersenAnne M LandauBente Finsen

Published in: Alzheimer's research & therapy (2019)

The progression of cerebral amyloidosis is associated with neuroinflammation and decreased presynaptic markers of serotonergic integrity and activity. The Aβ40-induced reduction in the uptake kinetics of [3H]5-HT suggests that the activity of SERT, and potentially the effects of SERT antagonism, depend on the levels of interstitial Aβ40.

Keyphrases

traumatic brain injury
lipopolysaccharide induced
lps induced
cerebral ischemia
cognitive impairment
subarachnoid hemorrhage
inflammatory response
oxidative stress
multiple myeloma
drug induced