Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children.

Nidhi P GoyalSara Brin RosenthalChanod NasamranCynthia A BehlingJorge E AngelesMark H FishbeinKathryn E HarlowAjay K JainJean P MollestonKimberly P NewtonPatricia Ugalde-NicaloStavra A XanthankosKatherine YatesNicholas J SchorkKathleen M FischJeffrey B Schwimmernull null

Published in: Hepatology (Baltimore, Md.) (2022)

This study demonstrated disease-associated SNPs in children with NAFLD. In particular, rs6006473 was highly associated with severity of fibrosis. These hypothesis-generating results support future mechanistic studies of development of adverse outcomes such as fibrosis and generation of therapeutic targets for NAFLD in children.

Keyphrases

young adults
gene expression
genome wide