Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release.
Achille AnselmoDerk FrankLaura PapaChiara Viviani AnselmiElisa Di PasqualeMarta MazzolaCristina PanicoFrancesca ClementeCristiana SoldaniChristina PagiatakisRabea HinkelRuth ThalmannRainer Gerhard Kozlik-FeldmannMichele MiragoliPierluigi CarulloMarco VacchianoAntonio Chaves-SanjuanNadia SantoMaria Angela LosiMatteo Carlo FerrariAnnibale Alessandro PucaVincent ChristiansenHatim SeoudySandra Freitag-WolfNorbert FreyAstrid DempfleMark MercolaGiovanni EspositoCarlo BriguoriChristian KupattGianluigi CondorelliPublished in: European heart journal (2021)
We identified circulating CD172a+ EVs as cardiac derived, showing their release and function and providing evidence for their prognostic potential in aortic stenosis patients.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- end stage renal disease
- aortic valve replacement
- transcatheter aortic valve replacement
- transcatheter aortic valve implantation
- newly diagnosed
- chronic kidney disease
- aortic valve
- peritoneal dialysis
- prognostic factors
- heart failure
- coronary artery disease
- patient reported outcomes
- climate change
- atrial fibrillation