Endotheliopathy in Acute COVID-19 and Long COVID.
Alice Georgia VassiliouCharikleia S VrettouChrysi KeskinidouIoanna DimopoulouAnastasia KotanidouStylianos E OrfanosPublished in: International journal of molecular sciences (2023)
The pulmonary endothelium is a highly regulated organ that performs a wide range of functions under physiological and pathological conditions. Since endothelial dysfunction has been demonstrated to play a direct role in sepsis and acute respiratory distress syndrome, its role in COVID-19 has also been extensively investigated. Indeed, apart from the COVID-19-associated coagulopathy biomarkers, new biomarkers were recognised early during the pandemic, including markers of endothelial cell activation or injury. We systematically searched the literature up to 10 March 2023 for studies examining the association between acute and long COVID-19 severity and outcomes and endothelial biomarkers.
Keyphrases
- coronavirus disease
- sars cov
- acute respiratory distress syndrome
- respiratory syndrome coronavirus
- liver failure
- endothelial cells
- respiratory failure
- extracorporeal membrane oxygenation
- systematic review
- nitric oxide
- adipose tissue
- mechanical ventilation
- multidrug resistant
- high resolution
- mass spectrometry
- septic shock