Haematopoietic stem cell-derived immune cells have reduced X chromosome inactivation skewing in systemic lupus erythematosus.

Amy L RobertsAlessandro MoreaAriella AmarMagdalena WestSarah KarrarRhiannon LehanePhilip TomblesonDeborah Cunningham GrahmanJohn A ReynoldsChloe C Y WongDavid L Morris Kerrin S Small Timothy J Vyse

Published in: Annals of the rheumatic diseases (2024)

These results refute current views on XCI-skew in autoimmunity and suggest, in lupus, XCI patterns of immune cells reflect the impact of disease state, specifically interferon signalling, on the haematopoietic stem cells from which they derive.

Keyphrases

systemic lupus erythematosus
disease activity
copy number
rheumatoid arthritis
gene expression
immune response
celiac disease