Genetic variation at ERBB3/IKZF4 and sexual dimorphism in epitope spreading in single autoantibody-positive relatives.

Julie Vandewalle Bart J Van der Auwera Henna Amin Erik Quartier Aster K Desouter Sylvie Tenoutasse Pieter Gillard Christophe E M De Block Bart Keymeulen Frans K Gorus Mark Van de Casteelenull null

Published in: Diabetologia (2021)

In siblings and offspring of type 1 diabetes patients, polymorphism in region ERBB3/IKZF4 may affect disease progression at the level of epitope spreading in female individuals. Our findings suggest that interaction between sex and ERBB3/IKZF4 may contribute to the post-pubertal male excess in type 1 diabetes.

Keyphrases

acute lymphoblastic leukemia
type diabetes
end stage renal disease
tyrosine kinase
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
mental health
cardiovascular disease
monoclonal antibody
intellectual disability
metabolic syndrome
skeletal muscle
weight loss