Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma.

Hampartsoum B BarsoumianRishab RamapriyanAhmed I YounesMauricio S CaetanoHari MenonNathan I ComeauxTaylor R CushmanJonathan E SchoenhalsAlexandra P CadenaTimothy P ReillyDawei ChenFatemeh MasrorpourAilin LiDavid S HongAdi DiabQuynh-Nhu NguyenIsabella C Glitza OlivaRenata FerrarottoStephen G ChunMaria Angelica CortezJames Welsh

Published in: Journal for immunotherapy of cancer (2021)

Our data extend the benefits of low-dose XRT to reprogram the tumor environment and improve the infiltration and function of effector immune cells into secondary tumors.

Keyphrases

low dose
immune response
high dose
dendritic cells
electronic health record
regulatory t cells
machine learning
toll like receptor
radiation induced
artificial intelligence
replacement therapy
smoking cessation