Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.

Burak Tan Ercan Babur Nihal Toy Buse Günaydın Nurcan Dursun Cem Süer

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2022)

Impaired LTP that occurs with aging may be among the underlying causes of dementia in relatively older ages, and l-thyroxine treatment restores this impaired LTP. In addition, the phosphorylation level of Tau epitopes known to play a role in the pathogenesis of Alzheimer's disease may support a critical role in the modulation of synaptic plasticity in hyperthyroidism.

Keyphrases

cerebrospinal fluid
middle aged
mild cognitive impairment
cognitive decline
high glucose
diabetic rats
physical activity
cognitive impairment
drug induced
combination therapy
protein protein
oxidative stress
protein kinase
small molecule
replacement therapy
stress induced