Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model.

Hideki FuruyaKazukuni HayashiYoshiko ShimizuNari KimYutaro TsukikawaRunpu ChenYijun SunOwen T M ChanIan PaganoRafael PeresKanani HokutanFumie IgariKeith S ChanCharles J Rosser

Published in: Journal of translational medicine (2020)

These results indicate that serpin compensation pathway, specifically PAI-2 overexpression in this model, supports bladder cancer development when oncoprotein PAI-1 is deleted. Further investigations into PAI-1 are necessary in order to identify true potential targets for bladder cancer therapy.

Keyphrases

cancer therapy
mouse model
cell proliferation
transcription factor
spinal cord injury
drug delivery
high glucose
diabetic rats
endothelial cells
drug induced