Aldose reductase promotes diet-induced obesity via induction of senescence in subcutaneous adipose tissue.

Devi ThiagarajanNosirudeen QuadriShabnam JawaharHylde ZirpoliCarmen Hurtado Del PozoRaquel López-DíezSyed Nurul HasanGautham YepuriPaul F GuggerBrian S FinlinPhilip A KernKenneth GabbayAnn Marie SchmidtRavichandran Ramasamy

Published in: Obesity (Silver Spring, Md.) (2022)

AKR1B1/Akr1b3 modulation of senescence in subcutaneous adipose tissue contributes to aberrant metabolic responses to high-fat feeding. These data unveil new opportunities to target these pathways to combat obesity.

Keyphrases

adipose tissue
insulin resistance
high fat diet induced
metabolic syndrome
high fat diet
weight loss
dna damage
type diabetes
endothelial cells
weight gain
skeletal muscle
stress induced
electronic health record
big data
body mass index
machine learning
oxidative stress
physical activity
data analysis