Repeated lipopolysaccharide exposure leads to placental endotoxin tolerance.

Maureen L KimCaroline MaloneyNatalia KlimovaEllen GurzendaXinhua LinYuko AritaTreasure WalkerMelissa J FazzariNazeeh Hanna

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

Repeated LPS exposure of human second-trimester placental tissues induced endotoxin tolerance. We speculate that endotoxin tolerance at the maternal-fetal interface will protect the fetus from exaggerated inflammatory responses after repeated infectious exposure.

Keyphrases

inflammatory response
endothelial cells
gene expression
pregnancy outcomes
diabetic rats
immune response
lps induced
induced pluripotent stem cells
drug induced
birth weight