Evaluation of BRAF, RAS, RET/PTC, and PAX8/PPARg alterations in different Bethesda diagnostic categories: A multicentric prospective study on the validity of the 7-gene panel test in 1172 thyroid FNAs deriving from different hospitals in South Italy.
Claudio BellevicineIlaria MigliaticoRoberta SgarigliaMariantonia NacchioElena VigliarPasquale PisapiaAntonino IaccarinoDario BruzzeseFrancesco FondericoDomenico SalvatoreBernadette BiondiStefania MasoneVincenzo NovizioFrancesco ScavuzzoDomenico SerinoMaurizio De PalmaMaria Grazia ChiofaloGerardo BottiLuciano PezzulloVincenzo NuzzoStefano SpieziaGiovanni De ChiaraSergio IorioGiovanni ConzoGiovanni DocimoAntongiulio FaggianoMassimo BongiovanniUmberto MalapelleAnnamaria ColaoMaria TriassiGiancarlo Tronconenull nullPublished in: Cancer cytopathology (2019)
The 7-gene panel test improves the preoperative risk stratification of indeterminate thyroid FNAs, especially when considering the biologic significance of the different types of mutations. Moreover, the rate of mutation-positive FNAs is related to the risk of malignancy of each diagnostic class.