Pharmacokinetics, safety, and activity of trabectedin as first-line treatment in elderly patients who are affected by advanced sarcoma and are unfit to receive standard chemotherapy: A phase 2 study (TR1US study) from the Italian Sarcoma Group.
Federica GrossoLorenzo D'AmbrosioMassimo ZucchettiToni IbrahimStefano TamberiCristina MatteoEliana RulliDanila ComandiniEmanuela PalmeriniGiacomo Giulio BaldiAndrea DeCensiMarina BergaglioDomenico MarraEmanuela MarchesiGiacomo SiriMaurizio D'IncalciGiovanni GrignaniPublished in: Cancer (2020)
Trabectedin can be administered safely to elderly patients with STS who are unfit to receive anthracyclines. Pharmacokinetics in the elderly population was superimposable to historical data.