Drug target ranking for glioblastoma multiforme.
Radhika S SarafShaghayegh AgahAniruddha DattaXiaoqian JiangPublished in: BMC biomedical engineering (2021)
Given the genetic profile of a GBM tumor, the Boolean model can predict the most effective targets for treatment. We also identified two-drug combinations that could be more effective in killing GBM cells than conventional chemotherapeutic agents. The non-cancer drug Aspirin could potentially increase the cytotoxicity of TMZ in GBM patients.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- induced apoptosis
- low dose
- peritoneal dialysis
- adverse drug
- cell cycle arrest
- type diabetes
- cardiovascular events
- emergency department
- gene expression
- dna methylation
- young adults
- cell death
- antiplatelet therapy
- percutaneous coronary intervention
- copy number
- pi k akt
- childhood cancer