Oxidative stress and Liver X Receptor agonist induce hepatocellular carcinoma in Non-alcoholic steatohepatitis model.

Yoshio ShimizuTakafumi TamuraAkira KemmochiYohei OwadaYusuke OzawaKatsuji HisakuraTakashi MatsuzakaHitoshi ShimanoNoriyuki NakanoShingo SakashitaTatsuya OdaNobuhiro Ohkohchi

Published in: Journal of gastroenterology and hepatology (2020)

By combining long-term LXR agonist stimulation with oxidative stress and a high-fat diet, we successfully reproduced liver conditions in mice similar to those in humans with NASH and progression to HCC. Our results provide new insight into NASH-related HCC progression and therapy.

Keyphrases

high fat diet
oxidative stress
insulin resistance
adipose tissue
dna damage
diabetic rats
ischemia reperfusion injury
high fat diet induced
induced apoptosis
type diabetes
stem cells
metabolic syndrome
mesenchymal stem cells
heat shock
liver fibrosis