Decreased Macrophage Autophagy Promotes Liver Injury and Inflammation from Alcohol.
Ghulam IlyasFrancesca CingolaniEnpeng ZhaoKathryn TanakaMark J CzajaPublished in: Alcoholism, clinical and experimental research (2019)
Macrophage autophagy functions to prevent liver injury from alcohol. This protection is mediated in part by down-regulation of inflammasome-dependent and inflammasome-independent hepatic inflammation. Therapies to increase autophagy may be effective in this disease through anti-inflammatory effects on macrophages.