Hematopoietic Cell Transplantation for Systemic Sclerosis-A Review.
Daniel LevinMohammed S OsmanCaylib DurandHyein KimIman HemmatiKareem JamaniJonathan G HowlettKerri A JohannsonJason WeatheraldMatthew WooJason LeeJan StorekPublished in: Cells (2022)
Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease associated with significant morbidity and mortality. Conventional immunosuppressive therapies demonstrate limited efficacy. Autologous hematopoietic stem cell transplantation (HCT) is more efficacious but carries associated risks, including treatment-related mortality. Here, we review HCT as a treatment for SSc, its efficacy and toxicity in comparison to conventional therapies, and the proposed mechanisms of action. Furthermore, we discuss the importance of and recent developments in patient selection. Finally, we highlight the knowledge gaps and future work required to further improve patient outcomes.
Keyphrases
- systemic sclerosis
- interstitial lung disease
- healthcare
- acute myeloid leukemia
- oxidative stress
- rheumatoid arthritis
- type diabetes
- case report
- cell therapy
- cardiovascular events
- combination therapy
- coronary artery disease
- signaling pathway
- mesenchymal stem cells
- risk factors
- climate change
- current status
- smoking cessation