Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice.
Yun LiuHongqiao LiYoshie SugiuraWeiping HanGilbert GallardoMikhail KhvotchevYinan ZhangEge T KavalaliThomas C SüdhofWeichun LinPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2015)
Degeneration of motor nerve terminals occurs in amyotrophic lateral sclerosis (ALS) patients as well as in mouse models of ALS, leading to progressive paralysis. What causes a motor nerve terminal to degenerate remains unknown. Here we report on transgenic mice expressing a ubiquitinated synaptic vesicle protein (Ub(G76V)-GFP-Syb2) that develop progressive degeneration of motor nerve terminals. These mice may serve as a model for further elucidating the underlying cellular and molecular mechanisms of presynaptic nerve terminal degeneration.
Keyphrases
- peripheral nerve
- multiple sclerosis
- end stage renal disease
- mouse model
- high fat diet induced
- chronic kidney disease
- newly diagnosed
- small molecule
- prognostic factors
- peritoneal dialysis
- type diabetes
- metabolic syndrome
- adipose tissue
- insulin resistance
- skeletal muscle
- binding protein
- protein protein
- prefrontal cortex