CompCorona: A web application for comparative transcriptome analyses of coronaviruses reveals SARS-CoV-2-specific host response.

Rana Salihoğlu Fatih Saraçoğlu Mustafa Sibai Talip Zengin Başak Abak Masud Onur Karasoy Tuğba Süzek

Published in: Turkish journal of biology = Turk biyoloji dergisi (2023)

Our findings suggest that infection by SARS-CoV-2 might induce pulmonary epithelial dysfunction, a phenomenon not observed in cells infected by other CoVs. The publicly available CompCorona tool, along with the preprocessed datasets of cells infected by various CoVs, constitutes a valuable resource for further research into CoV-associated syndromes.

Keyphrases

sars cov
induced apoptosis
respiratory syndrome coronavirus
cell cycle arrest
oxidative stress
pulmonary hypertension
gene expression
endoplasmic reticulum stress
genome wide
single cell