Markers of renal fibrosis: How do they correlate with podocyte damage in glomerular diseases?
Tiago Giulianni LopesMaysa Lucena de SouzaVinicius Duval da SilvaMariane Dos SantosWilliam Israel Cardoso da SilvaThiago Pereira ItaquyHenrique Iahnke GarbinFrancisco Veríssimo VeronesePublished in: PloS one (2019)
In patients with glomerular diseases, the mRNA of TGF-β1, CTGF, and VEGF-A correlated positively with the extent of renal fibrosis, and the positive area of fibrosis was larger in the podocytopathies and in DRD as measured by Sirius Red. The pathways connecting podocyte damage and activation of profibrotic factors to kidney tissue fibrosis need to be better investigated.