Improved metal allergen reactivity of artificial skin models by integration of Toll-like receptor 4-positive cells.

Verena G FringsDamaris MüllerGabriel StorzAngela RossiHelga SennefelderChristian AdamMatthias GoebelerFlorian K Groeber-BeckerMarc Schmidt

Published in: Contact dermatitis (2019)

Our data suggest that FTSE or DC/RhE co-culture models can circumvent the shortcomings of RhE assays, and combine the benefits of complex and monoculture-based test systems in a single assay.

Keyphrases

toll like receptor
nuclear factor
induced apoptosis
inflammatory response
high throughput
immune response
cell cycle arrest
electronic health record
dendritic cells
soft tissue
signaling pathway
oxidative stress
wound healing
single cell