LGALS3 cfDNA methylation in seminal fluid as a novel prostate cancer biomarker outperforming PSA.

Irena AbramovicIvan PezeljLeo DumbovicLucija Skara AbramovicTonci VodopicStela BulimbasicGoran StimacFloriana Bulic-JakusTomislav KulisAna Katusic BojanacDavor TomasMonika UlamecNino Sincic

Published in: The Prostate (2024)

The DNA hypermethylation of the LGALS3 gene represents an event specific to PCa development. In conclusion, LGALS3 cfDNA methylation in seminal fluid discriminates early PCa and BPH presenting itself as a powerful novel PCa biomarker highly outperforming PSA.

Keyphrases

prostate cancer
genome wide
radical prostatectomy
dna methylation
circulating tumor
copy number
single molecule
benign prostatic hyperplasia
cell free
case report
lower urinary tract symptoms
nucleic acid