Acute ischemia induces spatially and transcriptionally distinct microglial subclusters.
Huiya LiPinyi LiuBing ZhangZengqiang YuanMengdi GuoXinxin ZouYi QianShiji DengLiwen ZhuXiang CaoTao TaoShengnan XiaXinyu BaoYun XuPublished in: Genome medicine (2023)
ICAM could induce excessive neuroinflammation, aggravating brain injury, whereas IPAM probably exhibit neuroprotective features, which could be essential for the homeostasis and survival of cells in the penumbra. Our findings provide a biological basis for targeting specific microglial subclusters as a potential therapeutic strategy for ischemic stroke.
Keyphrases
- brain injury
- cerebral ischemia
- lipopolysaccharide induced
- subarachnoid hemorrhage
- lps induced
- inflammatory response
- induced apoptosis
- neuropathic pain
- liver failure
- cell cycle arrest
- respiratory failure
- weight gain
- atrial fibrillation
- traumatic brain injury
- endoplasmic reticulum stress
- blood brain barrier
- cancer therapy
- oxidative stress
- signaling pathway
- spinal cord
- cognitive impairment
- spinal cord injury
- body mass index
- cell proliferation
- cell death
- free survival
- extracorporeal membrane oxygenation
- drug delivery
- mechanical ventilation