Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs.

Han-Mo YangJoo-Eun LeeJu-Young KimJihye YouJoonoh KimHak Seung LeeHee Min YooMin Gyu KongJung-Kyu HanHyun-Jai ChoKyung Woo ParkHyun-Jae KangBon-Kwon KooYoung-Bae ParkHyo-Soo Kim

Published in: Biomaterials research (2023)

Our findings showed that abnormal calcium handling in sarco/endoplasmic reticulum could be induced by the enhanced SERCA2a activity in patients with VSA, leading to spasm. Such novel mechanisms of coronary artery spasm could be useful for drug development and diagnosis of VSA.

Keyphrases

coronary artery
endoplasmic reticulum
peripheral blood
pulmonary artery
rheumatoid arthritis
single cell
cell therapy
pulmonary arterial hypertension