Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry.

Jwala Priyadarsini SivaccumarAntonio LeonardiEmanuela Iaccarino Giusy Corvino Luca Sanguigno Angela Nebbioso Rosita RussoMariangela VallettaDebora LatinoDomenica CapassoNunzianna DotiMenotti Ruvo Annamaria Sandomenico

Published in: International journal of molecular sciences (2021)

The new anti-PRAME mAb recognizes the folded protein on the surface of cell membranes suggesting that the antibody's epitope is well exposed. BLI sensor chips can be used to identify antibody epitopes.

Keyphrases

monoclonal antibody
single cell
cell therapy
high speed
protein protein
bioinformatics analysis
bone marrow
small molecule
mass spectrometry