The effect and mechanism of low-dose esketamine in neuropathic pain-related depression-like behavior in rats.

Lijuan WangShuwu ZhaoJiali ShaoChen Su

Published in: Brain research (2024)

Low-dose Esketamine appeared to relieve depression-like behavior induced by neuropathic pain. The Homer1a-mGluR5 signaling pathway might be the mechanism of antidepressant effect of Esketamine.

Keyphrases

neuropathic pain
low dose
spinal cord
spinal cord injury
signaling pathway
depressive symptoms
high dose
sleep quality
major depressive disorder
pi k akt
epithelial mesenchymal transition
cell proliferation
drug induced