Characterization of Extracranial Giant Cell Arteritis with Intracranial Involvement and its Rapidly Progressive Subtype.

Carolin BeukerMaximilian Christian WanknerThomas Raphael MeinelJan-Kolja StreckerAntje Schmidt-PogodaWolfram SchwindtAndreas Schulte-MecklenbeckCatharina GrossHeinz WiendlPeter J BarthBernd EckertThomas Raphael MeinelMarcel ArnoldJens SchaumbergSchulamith KrügerMilani Deb-ChatterjiTim MagnusJoachim RötherJens Minnerup

Published in: Annals of neurology (2021)

Typical characteristics of GCA, headache, and an elevated ESR, are frequently absent in patients with intracranial involvement. However, differentiation of intracranial GCA from atherosclerosis can be facilitated by the typical pattern of vertebral artery stenosis. About one-third of patients with intracranial GCA had a rapid progressive course with poor outcome. IL-17 and IL-6 may represent potential future treatment targets. ANN NEUROL 2021;90:118-129.

Keyphrases

optic nerve
giant cell
multiple sclerosis
cardiovascular disease
type diabetes
risk assessment
neural network