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Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination.

Peter M CarlsonRavi B PatelJen BirstlerMatthew RodriquezClaire SunAmy K ErbeAmber M BatesIan MarshJoseph GrudzinskiReinier HernandezAlexander A PieperArika S FeilsAlexander L RakhmilevichJamey P WeichertBryan P BednarzPaul M SondelZachary S Morris
Published in: Journal for immunotherapy of cancer (2023)
We report a novel use for low-dose RT, not as a direct antitumor modality but as an immunomodulator capable of driving and expanding antitumor immunity against metastatic tumor sites following ISV.
Keyphrases
  • low dose
  • squamous cell carcinoma
  • small cell lung cancer
  • high dose
  • radiation therapy