Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination.
Peter M CarlsonRavi B PatelJen BirstlerMatthew RodriquezClaire SunAmy K ErbeAmber M BatesIan MarshJoseph GrudzinskiReinier HernandezAlexander A PieperArika S FeilsAlexander L RakhmilevichJamey P WeichertBryan P BednarzPaul M SondelZachary S MorrisPublished in: Journal for immunotherapy of cancer (2023)
We report a novel use for low-dose RT, not as a direct antitumor modality but as an immunomodulator capable of driving and expanding antitumor immunity against metastatic tumor sites following ISV.