Invasiveness of Ventilation Therapy Is Associated to Prevalence of Secondary Bacterial and Fungal Infections in Critically Ill COVID-19 Patients.
Marie Louise de HesselleStefan BorgmannSiegbert RiegJörg Janne VehreshildChristoph D SpinnerCarolin E M JakobMartin HowerMelanie StecherDaniel EbertFrank HansesJulia Schumannnull On Behalf Of The Sarel InvestigatorsPublished in: Journal of clinical medicine (2022)
Superinfections are a fundamental critical care problem, and their significance in severe COVID-19 cases needs to be determined. This study analyzed data from the Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort focusing on intensive care patients. A retrospective analysis of patient data from 840 cases of COVID-19 with critical courses demonstrated that co-infections were frequently present and were primarily of nosocomial origin. Furthermore, our analysis showed that invasive therapy procedures accompanied an increased risk for healthcare-associated infections. Non-ventilated ICU patients were rarely affected by secondary infections. The risk of infection, however, increased even when non-invasive ventilation was used. A further, significant increase in infection rates was seen with the use of invasive ventilation and even more so with extracorporeal membrane oxygenation (ECMO) therapy. The marked differences among ICU techniques used for the treatment of COVID-19-induced respiratory failure in terms of secondary infection risk profile should be taken into account for the optimal management of critically ill COVID-19 patients, as well as for adequate antimicrobial therapy.
Keyphrases
- sars cov
- respiratory failure
- extracorporeal membrane oxygenation
- mechanical ventilation
- acute respiratory distress syndrome
- coronavirus disease
- end stage renal disease
- healthcare
- intensive care unit
- ejection fraction
- newly diagnosed
- respiratory syndrome coronavirus
- prognostic factors
- staphylococcus aureus
- chronic kidney disease
- electronic health record
- early onset
- peritoneal dialysis
- big data
- high glucose
- risk factors
- patient reported outcomes
- stem cells
- bone marrow
- cystic fibrosis
- endothelial cells
- escherichia coli
- artificial intelligence
- minimally invasive
- diabetic rats
- health information
- combination therapy
- drug induced