Study of diffusion-weighted magnetic resonance imaging in the evaluation of the response to AAV2-VEGF-Trap neoadjuvant treatment in a triple-negative breast cancer animal model.
Jianhua LiPengjin ZhuLei WangLi YangLiqun ZouFabao GaoPublished in: Cancer medicine (2019)
AAV2-VEGF-Trap inhibits TNBC growth though inhibiting tumor neovascularization with a single intravenous injection, and AAV2-VEGF-Trap exhibits a synergistic effect when used in combination with paclitaxel for TNBC neoadjuvant therapy. In vivo fluorescence imaging can detect the anti-angiogenesis effect of AAV2-VEGF-Trap early and noninvasively. DW-MRI can longitudinally monitor the neoadjuvant efficacy of TNBC.
Keyphrases
- vascular endothelial growth factor
- endothelial cells
- rectal cancer
- gene therapy
- fluorescence imaging
- diffusion weighted
- contrast enhanced
- locally advanced
- lymph node
- magnetic resonance imaging
- photodynamic therapy
- squamous cell carcinoma
- computed tomography
- radiation therapy
- high dose
- stem cells
- diffusion weighted imaging
- mesenchymal stem cells
- bone marrow