Selaginellin Derivatives from Selaginella tamariscina and Their Upregulating Effects on Low-Density Lipoprotein Receptor Expression.
Sunmin WooHee-Sung ChaeJinwoong KimYoung Won ChinPublished in: Journal of natural products (2021)
Two new dimeric selaginellins, diselaginellins C and D (1 and 2), a new unusual derivative, selapiginellin A (4), a new selaginpulvilin U (5), and a known derivative, diselaginellin A (3), were isolated from Selaginella tamariscina (P. Beauv.) Spring. Among these compounds, selapiginellin A (4) is the first naturally occurring compound comprising an ether-linked dimer of a selaginellin and a selaginpulvilin. The absolute configurations of 1, 2, and 4 were elucidated by spectroscopic data analyses. Compound 5 was found to regulate mRNA expression of the low-density lipoprotein receptor (LDLR) gene and LDLR-related genes.
Keyphrases
- low density lipoprotein
- molecular docking
- electronic health record
- water soluble
- copy number
- genome wide
- big data
- ionic liquid
- dna methylation
- genome wide identification
- gene expression
- machine learning
- binding protein
- structure activity relationship
- artificial intelligence
- deep learning
- molecular dynamics simulations