Population pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis during and after cardiopulmonary bypass.
Christer RimmlerChristian LanckohrMiriam MittrupHenryk WelpGudrun WürthweinDagmar HornManfred FobkerBjörn EllgerGeorg HempelPublished in: British journal of clinical pharmacology (2020)
Dosing recommendations for cefuroxime as perioperative antibiotic prophylaxis in cardiac surgery are sufficient to reach plasma unbound concentration to cover S. aureus during the operation. Target attainment is not achieved in the postoperative period. Continuous infusion of cefuroxime may optimize target attainment.