What Is the "Relevant" Amyloid β42 Concentration?
Jevgenij A RaskatovPublished in: Chembiochem : a European journal of chemical biology (2019)
Alzheimer's amyloid beta can perform a wide variety of actions that are highly concentration dependent. This viewpoint aims to provide a framework for basic considerations on what might be considered brain-relevant concentrations of the peptide. Some implications for the therapeutic implementation of the recently emerged oligomer-to-fibril strategy are discussed.