Acute kidney injury in patients treated with anti-programmed death receptor-1 for advanced melanoma: a real-life study in a single-centre cohort.

Claire SteinStéphane BurteyJulien ManciniMarion PelletierMarion SalléePhilippe BrunetPhilippe BerbisJean Jacques GrobStéphane HonoréCaroline GaudyNoémie Jourde-Chiche

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)

AKI is common in patients treated with anti-PD1 for advanced melanoma but is mostly prerenal and favoured by the use of RAASi; renal irAE is rare. PPI and corticosteroids were associated with poor survival in this population, while overweight/obesity was protective.

Keyphrases

weight loss
weight gain
metabolic syndrome
acute kidney injury
insulin resistance
type diabetes
skin cancer
physical activity
high fat diet induced
free survival
basal cell carcinoma
skeletal muscle
binding protein