Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model.

Shangbin CuiZhiyu ZhouXu ChenFuxin WeiRobert Geoffrey Richards Mauro Alini Sybille Grad Zhen Li

Published in: JOR spine (2021)

Our study revealed different DEGs, pathways, biological process and PPI networks involved in post-traumatic IVD degeneration. These findings will advance the understanding of the pathogenesis of IVD degeneration, and help to identify novel biomarkers for the disease diagnosis.

Keyphrases

single cell
gene expression
transcription factor
protein protein
oxidative stress
heat stress
network analysis