Association between preeclampsia and attention-deficit hyperactivity disorder: a population-based and sibling-matched cohort study.

Gillian M MaherC DalmanG W O'KeeffeP M KearneyF P McCarthyL C KennyA S Khashan

Published in: Acta psychiatrica Scandinavica (2020)

Exposure to preeclampsia or preeclampsia/SGA was associated with ADHD, independent of genetic/familial factors shared by siblings. However, it is important to note that sibling-matched analysis can only adjust for factors that are constant between pregnancies; therefore, residual confounding cannot be ruled out. Further research is needed to explore modifiable risk factors and identify those most-at-risk babies following delivery.

Keyphrases

attention deficit hyperactivity disorder
early onset
autism spectrum disorder
pregnancy outcomes
risk factors
working memory
gestational age
pregnant women
genome wide
gene expression
dna methylation